|Year : 2017 | Volume
| Issue : 2 | Page : 55-59
Aetiological factors and dimension of tympanic membrane perforation in Benin City, Nigeria
Johnson Ediale1, Paul R. O. C Adobamen1, Titus S Ibekwe2
1 Department of Ear, Nose and Throat, University of Benin Teaching Hospital, Benin City, Nigeria
2 Department of Otorhinolaryngology, University of Abuja Teaching Hospital, Gwagwalada, Abuja, Nigeria
|Date of Submission||07-Feb-2017|
|Date of Acceptance||14-Jul-2017|
|Date of Web Publication||15-Sep-2017|
Department of Ear, Nose and Throat, University of Benin Teaching Hospital, Benin City
Source of Support: None, Conflict of Interest: None
Background: Tympanic membrane (TM) perforation is a recognised cause of hearing loss in our environment. The integrity of the TM can be compromised by varying aetiological factors which are often preventable. TM perforation occurs in different dimensions which tend to influence the degree of hearing loss.
Aim: The aim of this study is to determine the aetiological factors and dimensions of TM perforation among adolescents and adults in Benin City.
Methods: This was a 1-year prospective study carried out from 1st July 2014 to 30th June 2015 at the Ear, Nose and Throat Clinic of University of Benin Teaching Hospital. Consecutive patients with TM perforation were examined using a hand-held otoscope as well as Firefly video otoscope and subsequently had an interviewer administered questionnaire. Data were analysed using Statistical Package for Social Sciences (SPSS) version 20 and ImageJ software.
Results: One hundred and forty-eight patients with TM perforation in either or both ears were studied. There were 67 (45.3%) males and 81 (54.7%) females; ratio of 1:1.2. Ages ranged from 10 to 64 years, with a mean age of 34.5 ± 15.7 years. Chronic suppurative otitis media (CSOM) was the major cause of TM perforation in this study, 148 (74.0%). The small perforation was predominant, 54 (55.1%) and 48 (47%) in the right and left ears, respectively while the central anterior perforation, 93 (46.5%) occurred commonly.
Conclusion: Central and small perforations were the predominant TM perforation while CSOM was the major cause of TM perforation.
Keywords: Aetiology, Benin City, perforation, tympanic membrane
|How to cite this article:|
Ediale J, Adobamen PR, Ibekwe TS. Aetiological factors and dimension of tympanic membrane perforation in Benin City, Nigeria. Port Harcourt Med J 2017;11:55-9
|How to cite this URL:|
Ediale J, Adobamen PR, Ibekwe TS. Aetiological factors and dimension of tympanic membrane perforation in Benin City, Nigeria. Port Harcourt Med J [serial online] 2017 [cited 2018 May 22];11:55-9. Available from: http://www.phmj.org/text.asp?2017/11/2/55/214864
| Introduction|| |
Tympanic membrane (TM) is the transparent oval-shaped, pearly gray membrane, which lies obliquely inside the ear canal demarcating the external ear from the middle ear. It is divided into two parts: the pars tensa and pars flaccida. The pars tensa forms the larger part of the TM while the pars flaccida forms the superior part also called Shrapnel's membrane., It is separated from the pars tensa by the anterior and posterior malleolar folds. An intact TM [Figure 1] plays a significant role in the conduction of sound waves across the middle ear and as well protects the middle ear cleft from infection. TM perforation is a condition where the TM has a hole in it, thereby establishing a direct communication between the external and middle ear. Perforation on the TM reduces the surface area available for sound pressure transmission on the one hand and allows sound waves to pass directly into the middle ear. As a result, the pressure gradient between the medial and lateral surfaces of the TM cancels out. This leads to impaired transmission of sound waves across the ossicular chain in the middle ear with a resultant reduction in hearing.
|Figure 1: Video otoscopy images of the right and left intact tympanic membrane|
Click here to view
TM perforation is the most common sequelae of middle ear infection. It is reported in approximately 10% of episodes where perforations tend to occur in the pars tensa; other causes of TM perforation include trauma; direct trauma, acoustic trauma, barotrauma, iatrogenic causes and middle ear tumors. A perforated ear drum due to trauma may heal spontaneously usually within 10 weeks, especially if it is of small size, centrally located and the edges are not displaced. However, ruptured ear drum due to chronic ear infection will often require treatment.
TM perforation can be classified according to the size and location of perforation on the TM. Sub categories based on the size of perforation could be small, medium, large or subtotal perforation., The locations vary from central, marginal or attic perforations. Central perforation could be anterior, posterior and inferior or subtotal while marginal perforation could be posterosuperior, anteroinferior or total. Anteroinferior perforations are the most common TM perforations., Central perforation implies that the perforation is within the pars tensa or with the annulus intact. For marginal perforation, there is destruction of the annulus and encroachment into the sulcus tympanicus. Attic perforations usually involve the pars flaccida and it is a pointer to the presence of cholesteatoma; an unsafe ear. A computer-based video otoscopy system is more appropriate in assessing TM perforation as it is more objective and provides a better view of the perforation which enhances better analysis of the size and location of perforation on the TM. The aim of this study was to determine the aetiological factors responsible for TM perforation as well as to categorize the various dimensions of TM perforation among adolescents and adults in Benin City.
| Methods|| |
This was a 1-year prospective study (1st July 2014–30th June 2015) conducted at the Ear, Nose and Throat Clinic of University of Benin Teaching Hospital (UBTH), Benin City, Nigeria. Ethical clearance was obtained from the Ethics and Research Committee, UBTH, before commencement of the study. Consecutive patients (10–64 years) presenting at the clinic during the study had their ears examined for TM perforation by ENT surgeons using head lights and battery-powered otoscope. Those eligible for the study gave informed consent and data were obtained from them through interviewer-administered questionnaire. The content of the questionnaire included serial number, information on personal data; age, sex, occupation, ear symptoms; hearing loss, tinnitus, ear pain, vertigo, ear discharge, duration of symptoms, past illness, use of ototoxic drugs, history of ear trauma and ear surgery. The ear of each patient with TM perforation was assessed using a Firefly DE 550 hand-held USB video otoscope, and images saved on the computer for the determination of the size of the TM perforation and location of the perforation on the TM. Saved images were analysed using the ImageJ (version 1.35 of Wayne Rasband, National Institute of Health, USA) geometrical analysis software package. The perforation margin was first outlined using a mouse, and thereafter, the boundary of the entire TM was identified and marked likewise [Figure 2]a. The area of the TM perforation (P) and the area of entire TM (T) were calculated, and the percentage of perforation (P/T × 100/1) was obtained [Figure 2]b.
|Figure 2: (a) Outline of area of tympanic membrane perforation and the entire tympanic membrane. (b) Area measurement of tympanic membrane perforation and the entire tympanic membrane: P = 89.1 mm, T = 602.5 mm. Size of perforation (% area) = 89.1/602.5 × 100 = 14.9%|
Click here to view
Data collected was analysed using Statistical Package for Social Sciences (SPSS) version 20 (SPSS version 20.0 Armonk, NY:IBM Corp) and results presented in tables and figure.
| Results|| |
A total of 200 ears from 148 patients out of the 162 patients with TM perforation in either or both ears were studied. Ages ranged from 10 to 64 years, with a mean age of 34.5 ± 15.7 years. A high proportion of the participants, 98 (66.3%), were within the younger age group of 10–39 years. There were 67 (45.3%) males and 81 (54.7%) females; ratio of 1:1.2. Students accounted for up to one-third, 49 (33.1%), of the study population [Table 1]. Unilateral TM perforation was more than the bilateral perforation; 96 (64.9%) for the former and 52 (35.1%) for the latter, respectively [Table 2]. The left ear recorded the higher number of TM perforation among the study ears, 102 (51.0%) [Table 3]. Tinnitus was the most common symptom reported by patients, 112 (75.7%) while ear pain was the least reported symptom, 52 (35.1%) [Table 4]. Chronic suppurative otitis media (CSOM) was the most common cause of TM perforation, 148 (74.0%) while trauma, 22 (11%) was the least cause of perforation on the TM [Figure 3]. The small perforation was predominant; 54 (55.1%) and 48 (47%) in the right and left ears, respectively while the central anterior perforation, 93 (46.5%) and central perforation, 83 (41.5%) occurred commonly [Table 5].
|Table 2: Laterality of tympanic membrane perforation among study participants (n=148)|
Click here to view
| Discussion|| |
TM perforation is an identifiable cause of hearing loss. The incidence is on the increase in the developing countries  due to malnutrition, overcrowding, frequent upper respiratory tract infections , encouraged by poverty and ignorance. The predominant age group was mainly the young population (10–39 years) [Table 1]. Similar studies in Nigeria were in agreement with the above finding., There was a female preponderance (54.7%), probably following the speculation that the health-seeking behaviour of females are better than males in the developing countries. The reasons behind this notion though not fully substantiated may be due to their peculiar health needs. Other studies , also showed a similar trend. The predominant students population is a reflection of the population distribution of Nigeria (60% youths) and may also be attributable to involvement in active and daring activities associated with trauma.
Unilateral TM perforation recorded a higher prevalence of 64.9% among the study participants [Table 2]. This was similar to the findings among adults in Nigeria-West Africa  where unilateral TM perforation accounted for 80% of cases in the study population. The left ears were marginally more perforated (51.0%), compared to the right ear [Table 3]. Although the reason for this could not be clearly defined, it appears that handedness may be a factor. Since most people are right handed, most hand slaps land on the left side of the face. In this study, tinnitus was the most prevalent symptoms (75%) [Table 4]. This is, however, comparable with the previous studies., With perforations on the TM, sound waves tend to strike the oval and round windows simultaneously, which tends to negate the middle ear baffle effect resulting in tinnitus and hearing loss.
The cause of TM perforation was predominantly due to CSOM (74%) [Figure 3]. In a study on the pattern of TM perforation in Ibadan, CSOM was the most common cause of TM perforation in about 91% of cases. This may be likely due to poorly treated acute suppurative otitis media (ASOM) in early childhood, with associated late presentation and low-socioeconomic status.,, In another study, trauma was found to be the major aetiological factor for TM perforation. Here, the population studied was, however, predisposed to trauma. Worrisome is the prevalence of trauma from hand slaps to the face, occasioned by domestic violence and assault with associated TM perforation. Documentations suggest that this has been on the increase in Nigeria.,
ASOM occurred more during the wet season, probably due to the high incidence of viral infections such as coryza, which if not well-treated could be complicated by ASOM. Although the scope of this study was not audiometric analysis, however, it has been observed that there is association between aetiological factors of TM perforation and severity of hearing loss among adults in Nigeria-West Africa. The severity of hearing loss was more common among patients with CSOM compared to those with other causes of TM perforation. This is probably due to the fact that patients with other causes of TM perforation such as ASOM and ear trauma seek medical care earlier than those with CSOM.
Video otoscopy assessment of the size of TM perforation showed that the sizes of perforation ranged from 2.0% to 92.0%, with a mean size of 31.7% ±21.4%. In an earlier study correlating TM perforation and hearing loss, the sizes of TM perforation ranged from 1.5%–89.0%. This computer-based measurement of size of TM perforation is precise, compared to the conventional battery-powered clinic otoscopy which is highly subjective.,
The small perforation (1%–25%) was more common in the right than the left ear; 55.1% and 47.0% respectively, while the larger perforations were more common in the left ear [Table 5]. We cannot presently hypothesise the reasons for this. In another study in Bengaluru, small-sized perforations were more common in a study done only on perforations resulting from ear trauma. This was contrary to what was obtained in a similar study  where the larger perforations predominated in both ears. This may be due to the classification adopted in the study where sizes of TM perforations of 40% and above were considered to be large perforation.
Most perforations were in the central anterior and central portions of the TM in both the right and left ears; 46.5% and 41.5%, respectively [Table 5]. The central portion of the pars tensa is the most dependent part of the TM;, hence, it is more predisposed to rupture. This may also be in keeping with the phenomenon of safe ear  (tubo tympanic disease) as it relates to CSOM. Earlier studies ,, showed the central TM perforations to be more common. The marginal perforation was the least common. Marginal perforation is usually located in the posterior and superior segments of the TM and often associated with the unsafe type of CSOM with the presence of cholesteatoma (attico antral disease). Its occurrence is rare with the advent of antibiotics.
Evaluation of the audiometric thresholds of the various dimensions of TM perforation would have made this study more encompassing. This is an arrear to consider in the future research.
| Conclusion|| |
The causes of TM perforation in this study were middle ear infections and trauma, with varying dimensions in sizes and location on the TM; the small and central perforations being predominant. Early presentation of patients to the ENT surgeon at the wake of unexplained ear symptoms could enhance prompt treatment to avert TM perforation complicating hearing loss.
Financial support and sponsorship
Conflicts of interest
There are no conflicts of interest.
| References|| |
Dhingra PL. Diseases of the ear. In: Dhingra PL, Dhingra S, editors. Diseases of Ear, Nose and Throat. 4th
ed. New Delhi: Elsevier, 2007; 3-13, 33, 67.
Voss SE, Rosowski JJ, Merchant SN, Peake WT. Non-ossicular signal transmission in human middle ears: Experimental assessment of the “acoustic route” with perforated tympanic membranes. J Acoust Soc Am 2007;122:2135-53.
Pickles JO. Physiology of hearing. In: Gleeson M, Browning GG, Burton MJ, Clarke R, Hibbert J, Jones NS, et al
., editors. Scott Brown's Otorhinolaryngology Head and Neck Surgery. 7th
ed., Vol. 3. London: Arnold, 2008; 3176-206.
Buttaravoli P, Leffler SM, editors. Perforated tympanic membrane (ruptured eardrum). In: Minor Emergencies. 3rd
ed. Philadelphia, PA: Mosby Elsevier, 2012; 145-6.
Kruger B, Tonndorf J. Tympanic membrane perforations in cats: Configurations of losses with and without ear canal extensions. J Acoust Soc Am 1978;63:436-41.
Rea P, Graham J. Acute otitis media in children. In: Gleeson M, Browning GG, Burton MJ, Clarke R, Hibbert J, Jones NS, et al.,
editors. Scott Brown's Otorhinolaryngology Head and Neck Surgery. 7th
ed., Vol. 1. London: Arnold, 2008; 912-27.
Tos M. Course of and sequelae to 248 petrosal fractures. Acta Otolaryngol 1973;75:353-4.
Hamilton J. Chronic Otitis media in childhood. In: Gleeson M, Browning GG, Burton MJ, Clarke R, Hibbert J, Jones NS, et al.,
editors. Scott Brown's Otorhinolaryngology Head and Neck Surgery. 7th
ed., Vol. 1. London: Arnold, 2008; 928-64.
Hsu CY, Chen YS, Hwang JH, Liu TC. A computer program to calculate the size of tympanic membrane perforations. Clin Otolaryngol Allied Sci 2004;29:340-2.
Saliba I, Abela A, Arcand P. Tympanic membrane perforation: Size, site and hearing evaluation. Int J Pediatr Otorhinolaryngol 2011;75:527-31.
Oluwole M, Mills RP. Tympanic membrane perforations in children. Int J Pediatr Otorhinolaryngol 1996;36:117-23.
Ritenour AE, Wickley A, Ritenour JS, Kriete BR, Blackbourne LH, Holcomb JB, et al.
Tympanic membrane perforation and hearing loss from blast overpressure in operation enduring freedom and operation Iraqi freedom wounded. J Trauma 2008;64:S174-8.
Gelfand SA. Essentials of Audiology. 3rd
ed. New York: Thieme Medical Publishers, 2009; 171-2.
Ibekwe TS, Adeosun AA, Nwaorgu OG. Quantitative analysis of tympanic membrane perforation: A simple and reliable method. J Laryngol Otol 2009;123:e2.
Ibekwe TS, Ijaduola GT, Nwaorgu OG. Tympanic membrane perforation among adults in West Africa. Otol Neurotol 2007;28:348-52.
Ologe FE, Nwawolo CC. Prevalence of chronic suppurative otitis media (CSOM) among school children in a rural community in Nigeria. Niger Postgrad Med J 2002;9:63-6. [Full text]
Afolabi OA, Aremu SK, Alabi BS, Segun-Busari S. Traumatic tympanic membrane perforation: An aetiological profile. BMC Res Notes 2009;2:232.
Olowookere SA, Ibekwe TS, Adeosun AA. Pattern of tympanic membrane perforation in Ibadan: A retrospective study. Ann Ib Postgrad Med 2008;6:31-3.
Buvinic M, Medici A, Fernandez E, Torres AC. Gender differentials in health. In: Jamison DT, Breman JG, Measham AR, Alleyne G, Claeson M, Evans DB, et al
., editors. Disease Control Priorities in Developing Countries. 2nd
ed. New York: Oxford University Press, 2006; 195-210.
Maharjan M, Kafle P, Bista M, Shrestha S, Toran KC. Observation of hearing loss in patients with chronic suppurative otitis media tubotympanic type. Kathmandu Univ Med J (KUMJ) 2009;7:397-401.
Onyeagwara NC, Okhakhu AL, Braimoh OE. A retrospective study of traumatic tympanic membrane perforation at the University of Benin Teaching Hospital, Nigeria. Ann Biomed Sci 2014;13:83-92.
Darley DS, Kellman RM. Otologic considerations of blast injury. Disaster Med Public Health Prep 2010;4:145-52.
Lasisi AO, Sulaiman OA, Afolabi OA. Socio-economic status and hearing loss in chronic suppurative otitis media in Nigeria. Ann Trop Paediatr 2007;27:291-6.
Amusa YB, Ijadunola IK, Onayade OO. Epidemiology of otitis media in a local tropical African population. West Afr J Med 2005;24:227-30.
Sarojamma DSR, Raj S, Satish HS. A clinical study of traumatic perforation of tympanic membrane. IOSR J Dent Med Sci 2014;13:24-8.
Orji FT, Agu CC. Patterns of hearing loss in tympanic membrane perforation resulting from physical blow to the ear: A prospective controlled cohort study. Clin Otolaryngol 2009;34:526-32.
Ibekwe TS, Nwaorgu OG, Ijaduola TG. Correlating the site of tympanic membrane perforation with hearing loss. BMC Ear Nose Throat Disord 2009;9:1.
Jones WS. Video otoscopy: Bringing otoscopy out of the “black box”. Int J Pediatr Otorhinolaryngol 2006;70:1875-83.
Sullivan RF. Video otoscopy in audiologic practice. J Am Acad Audiol 1997;8:447-67.
Bhusal CL, Guragain RP, Shrivastav RP. Size of typmanic membrane perforation and hearing loss. JNMA J Nepal Med Assoc 2006;45:167-72.
Maqbool M. Anatomy of the ear. In: Maqbool M, Maqbool S, editors. Text Book of Ear, Nose and Throat Diseases. 11th
ed. New Delhi: Jaypee Brothers Medical Publishers, 2007; 7-22.
[Figure 1], [Figure 2], [Figure 3]
[Table 1], [Table 2], [Table 3], [Table 4], [Table 5]