Port Harcourt Medical Journal

ORIGINAL ARTICLE
Year
: 2018  |  Volume : 12  |  Issue : 1  |  Page : 46--55

Prevalence and pattern of inflammatory dermatoses and skin cancers in highly active antiretroviral therapy-experienced and highly active antiretroviral therapy-naive patients in the University of Benin Teaching Hospital, Benin City, Nigeria


Roli Cynthia Madubuko, Abel Nze Onunu 
 Department of Medicine, University of Benin Teaching Hospital, Benin City, Nigeria

Correspondence Address:
Roli Cynthia Madubuko
Department of Medicine, University of Benin Teaching Hospital, Benin City
Nigeria

Introduction: Highly active antiretroviral therapy (HAART) reduces morbidity, mortality and prolong life in patients with human immunodeficiency virus (HIV) infection. Only a few studies have compared the prevalence and pattern of inflammatory dermatoses and skin cancers in HAART-naïve and HAART-experienced HIV-infected patients. Aim: The aim of this study was to determine the prevalence and pattern of inflammatory dermatoses and skin cancers in HAART-experienced and HAART-naive patients in the University of Benin Teaching Hospital, Benin City, Nigeria. Methods: This was a comparative cross-sectional study that involved 330 HAART-experienced patients and 330 HAART-naive patients. Patients were examined for inflammatory dermatoses and skin cancers. Skin biopsies were done where applicable for diagnostic accuracy. Results: The mean age of the HAART-experienced group and HAART-naïve group was 42.39 ± 10.1 years and 39.9 ± 11.2 years, respectively. The male-to-female ratio of the HAART-naive and HAART-experienced population was 1.9:1 and 3:1, respectively. The median CD4 count of the HAART-naive group was significantly lower than the HAART-experienced group (275.5 vs. 487 cells/μ P ≤ 0.01). Skin cancers were present in 1.8% of the HAART-naïve group but absent in HAART-experienced patients (P ≤ 0.01). The prevalence of inflammatory dermatoses was 36 (10.9%) in the HAART-naïve group and 8 (2.4%) in the HAART-experienced group (P < 0.01). Pruritic papular eruption was the most common inflammatory dermatoses in both groups with a prevalence of 7.6% and 1.2% in the HAART-naïve and HAART-experienced groups, respectively. Conclusion: Inflammatory dermatoses and skin malignancies were more common in HAART-naive HIV-infected patients compared to HAART-experienced patients. HAART may reduce the cutaneous morbidity in HIV patients.


How to cite this article:
Madubuko RC, Onunu AN. Prevalence and pattern of inflammatory dermatoses and skin cancers in highly active antiretroviral therapy-experienced and highly active antiretroviral therapy-naive patients in the University of Benin Teaching Hospital, Benin City, Nigeria.Port Harcourt Med J 2018;12:46-55


How to cite this URL:
Madubuko RC, Onunu AN. Prevalence and pattern of inflammatory dermatoses and skin cancers in highly active antiretroviral therapy-experienced and highly active antiretroviral therapy-naive patients in the University of Benin Teaching Hospital, Benin City, Nigeria. Port Harcourt Med J [serial online] 2018 [cited 2020 Aug 6 ];12:46-55
Available from: http://www.phmj.org/article.asp?issn=0795-3038;year=2018;volume=12;issue=1;spage=46;epage=55;aulast=Madubuko;type=0